Klf2^tm1Jml
Targeted Allele Detail

Summary

• Symbol: Klf2^tm1Jml
• Name: Kruppel-like transcription factor 2 (lung); targeted mutation 1, Jeffrey M Leiden
• MGI ID: MGI:3639349
• Synonyms: LKLF^-
• Gene: Klf2 Location: Chr8:73072906-73075498 bp, + strand Genetic Position: Chr8, 34.99 cM, cytoband C1
• Alliance: Klf2^tm1Jml page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44352
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire gene, including exons 1, 2 and 3 was replaced with a neomycin selection cassette. In situ hypbridization analysis on mutant embryos confirmed that no detectable transcript is expressed from this allele. (J:43131, J:44352)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf2 Mutation: 12 strains or lines available

References

• Original: J:44352 Kuo CT, et al., The LKLF transcription factor is required for normal tunica media formation and blood vessel stabilization during murine embryogenesis. Genes Dev. 1997 Nov 15;11(22):2996-3006
• All: 5 reference(s)