Cpt1c^tm1Mdln
Targeted Allele Detail

Summary

• Symbol: Cpt1c^tm1Mdln
• Name: carnitine palmitoyltransferase 1c; targeted mutation 1, M Daniel Lane
• MGI ID: MGI:3639356
• Gene: Cpt1c Location: Chr7:44608796-44624275 bp, - strand Genetic Position: Chr7, 29.07 cM, cytoband B2
• Alliance: Cpt1c^tm1Mdln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109455
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exons 1 and 2, encoding the transcription initiation site and the first transmembrane domain of the protein, with a neomycin resistance cassette. Western blot failed to detect protein in mutant brains. (J:109455)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cpt1c Mutation: 43 strains or lines available

References

• Original: J:109455 Wolfgang MJ, et al., The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7282-7
• All: 2 reference(s)