Tg(Mt1a-GPHB5)1Sok
Transgene Detail

Summary

• Symbol: Tg(Mt1a-GPHB5)1Sok
• Name: transgene insertion 1, Shannon L Okada
• MGI ID: MGI:3639358
• Transgene: Tg(Mt1a-GPHB5)1Sok Location: unknown
• Alliance: Tg(Mt1a-GPHB5)1Sok page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mt1a-GPHB5)1Sok expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  GPHB5 (122876)

  Gphb5

  (MGI:2156540)

• Mutation details: The human GPHB5 open reading frame was inserted into a vector containing the metallothionein-1 promoter and a consensus translation initiation sequence was placed upstream of the GPHB5 ATG. Introns from the rat INS2 and a human GH polyadenlyation signal sequence were cloned 5' and 3' of GPHB5 to enhance transcription. (J:105176)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105176 Okada SL, et al., A glycoprotein hormone expressed in corticotrophs exhibits unique binding properties on thyroid-stimulating hormone receptor. Mol Endocrinol. 2006 Feb;20(2):414-25
• All: 1 reference(s)