Tg(H2-K-Fosl1)1Wag
Transgene Detail

Summary

• Symbol: Tg(H2-K-Fosl1)1Wag
• Name: transgene insertion 1, Erwin F Wagner
• MGI ID: MGI:3639512
• Synonyms: fra-1^tg, Fra1 Tg
• Transgene: Tg(H2-K-Fosl1)1Wag Location: unknown
• Alliance: Tg(H2-K-Fosl1)1Wag page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(H2-K-Fosl1)1Wag expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fosl1 (MGI:107179)

• Mutation details: This transgene contains the murine Fosl1 gene fused to the major histocompatibility complex class I antigen H2-K^b promoter. To stabilize the Fosl1 mRNA and ensure expression in mesenchymal cells, the 3' long terminal repeat sequence of the FBJ-murine sarcoma virus was linked to the 3' end of the Fosl1 gene. Fosl1 mRNA is widely expressed in various organs, including bone. (J:64494)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:64494 Jochum W, et al., Increased bone formation and osteosclerosis in mice overexpressing the transcription factor fra-1. Nat Med. 2000 Sep;6(9):980-4
• All: 9 reference(s)