Itgb1^tm1.1Efu
Targeted Allele Detail

Summary

• Symbol: Itgb1^tm1.1Efu
• Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 1.1, Elaine Fuchs
• MGI ID: MGI:3639561
• Synonyms: Itgb1-
• Gene: Itgb1 Location: Chr8:129412135-129459681 bp, + strand Genetic Position: Chr8, 76.09 cM, cytoband E2
• Alliance: Itgb1^tm1.1Efu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:108331
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Insertion of loxP sites flanking the third exon of the Itgb1 gene. Crossing heterozygous mice with CMV-cre deleter mice to excise the floxed exon produced an Itgb1-deficient allele. (J:65039)

Expression

In Mice Carrying this Mutation:	28 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1 Mutation: 60 strains or lines available

References

• Original: J:108331 Chen H, et al., In vivo beta1 integrin function requires phosphorylation-independent regulation by cytoplasmic tyrosines. Genes Dev. 2006 Apr 15;20(8):927-32
• All: 4 reference(s)