Bwtn2^SM/J
QTL Variant Detail

Summary

• QTL variant: Bwtn2^SM/J
• Name: body weight at necropsy 2; SM/J
• MGI ID: MGI:3639925
• QTL: Bwtn2 Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 54.7 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci in the reference are reported here.

On mouse Chromosome 1 linkage to necropsy weight, Bwtn2 (body weight at necropsy 2), mapped to approximately 16 cM near D1Mit20 (LPR=2.68). The confidence interval of Bwtn2 spans 2 cM - 52 cM. Bwtn2 and previously identified adiposity QTL Adip1 (11 cM) may be identical. Linkage to long bone measurements, Lbn1 (long bones 1), mapped to 41 cM near D1Mit7 (LPR=27.9). The confidence interval of Lbn1 spans 46 cM - 54 cM. Previously identified QTL Skl1 (41 cM) may be identical to Lbn1. Potential candidate genes for Lbn1 include Twist2, Capn10, Inpp5d (57 cM), and Spp2.

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)