Org3^SM/J
QTL Variant Detail

Summary

• QTL variant: Org3^SM/J
• Name: organ weight 3; SM/J
• MGI ID: MGI:3639947
• QTL: Org3 Location: unknown Genetic Position: Chr4, cM position of peak correlated region/allele: 28.62 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: SM/J

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 4, linkage to liver weight, Org3 (organ weight 3), mapped to 21 cM near D4Mit163 (LPR=4.01). The confidence interval spans 8 cM - 28 cM.

Linkage to organ weight and bone length, Bod2 (bone length and organs 2), mapped to D4Mit17 (LPR=12.94). This locus affects necropsy body weight, spleen and kidney weights, and all 4 long bone measurements. The confidence interval spans 30 cM - 64 cM. Potential candidate genes mapping near Bod2 include Megf9 (formerly Egfl5), Trim32 (33 cM), and Tyrp1 (38 cM).

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)