Lmo7^tm1Tilg
Targeted Allele Detail

Summary

• Symbol: Lmo7^tm1Tilg
• Name: LIM domain only 7; targeted mutation 1, Shirley M Tilghman
• MGI ID: MGI:3639949
• Synonyms: Lmo^delta800
• Gene: Lmo7 Location: Chr14:101967393-102172146 bp, + strand Genetic Position: Chr14, 50.9 cM
• Alliance: Lmo7^tm1Tilg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83810
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: An 800kb deletion including the last 8 exons of Uchl3 and the entire Lmo7 gene was created using Cre-loxP recombination in ES cells to insert loxP sites at the breakpoints of the intended deletion. Targeting vectors were injected into AB2.2 ES cells and correctly targeted clones were electroporated with a Cre-expressing plasmid to excise the 800kb region. (J:83810)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmo7 Mutation: 106 strains or lines available

References

• Original: J:83810 Semenova E, et al., An engineered 800 kilobase deletion of Uchl3 and Lmo7 on mouse chromosome 14 causes defects in viability, postnatal growth and degeneration of muscle and retina. Hum Mol Genet. 2003 Jun 1;12(11):1301-12
• All: 1 reference(s)