Dp(16Dgcr14-Ufd1l)217Bld
Targeted Allele Detail

Summary

• Symbol: Dp(16Dgcr14-Ufd1l)217Bld
• Name: duplication, Chr 16, Antonio Baldini 217
• MGI ID: MGI:3640123
• Synonyms: Dp1, Dp(16Dgcr14-Ufd1l)217Bld, dup(16)(Es2el-Ufd1l)
• Gene: Dp(16Dgcr14-Ufd1l)217Bld Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57757
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Duplication
• Dp(16Dgcr14-Ufd1l)217Bld involves 42 genes/genome features (Gm26170, Gm26219, Gm15954 ...) View all
• Mutation details: A proximal loxP site was targeted into the Es2el gene. The targeting vector replaced a 200-bp fragment containing exon 4. A second loxP site was targeted into the Ufd1l gene, replacing a 4.5-kb fragment containing exons 2-3. Transient expression of Cre resulted in recombination between loxP sites on opposite chromosomes duplicating the 1.2 MB region from Es2el to Ufd1l. (J:57757)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dp(16Dgcr14-Ufd1l)217Bld Mutation: 1 strain or line available

References

• Original: J:57757 Lindsay EA, et al., Congenital heart disease in mice deficient for the DiGeorge syndrome region [see comments]. Nature. 1999 Sep 23;401(6751):379-83
• All: 3 reference(s)