Del(16Es2el-Sept5)3Bld
Targeted Allele Detail

Summary

• Symbol: Del(16Es2el-Sept5)3Bld
• Name: deletion, Chr 16, Antonio Baldini 3
• MGI ID: MGI:3640126
• Synonyms: Del(16Dgcr14-Sept5)3Bld, del(16)(Es2el-Cdcrel1), Del3Bld, Df(16)3, Df3
• Gene: Del(16Es2el-Sept5)3Bld Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67409
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(16Es2el-Sept5)3Bld involves 34 genes/genome features (Gm26219, Gm15954, Gm26170 ...) View all
• Mutation details: A proximal loxP site was targeted into the Es2el gene. The targeting vector replaced a 200-bp fragment containing exon 4. A second loxP site was introduced into the Sept5 gene, replacing exons 2-4. Embryonic stem cells that were double-targeted in trans were subjected to transient Cre expression and underwent recombination to produce a reciprocal deletion of the Es2el-Sept5 interval. (J:67409)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16Es2el-Sept5)3Bld Mutation: 1 strain or line available

References

• Original: J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
• All: 2 reference(s)