Del(16T10-Hira)4Bld
Targeted Allele Detail

Summary

• Symbol: Del(16T10-Hira)4Bld
• Name: deletion, Chr 16, Antonio Baldini 4
• MGI ID: MGI:3640127
• Synonyms: del(16)(T10-Hira), Del(16Tango2-Hira)4Bld, Del4Bld, Df(16)4, Df4
• Gene: Del(16T10-Hira)4Bld Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:67409
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutations: Intergenic deletion, Intragenic deletion
• Del(16T10-Hira)4Bld involves 25 genes/genome features (Gm26170, Gm26219, Tango2 ...) View all
• Mutation details: In an ES cell line in which a loxP site previously had been inserted into the Hira gene by homologous recombination, a second loxP site was inserted into the T10 gene using a retrovirus. Transient cre-expression in the ES cells resulted in deletion of a ~ 1Mb region from T10 to Hira. (J:67409)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16T10-Hira)4Bld Mutation: 1 strain or line available

References

• Original: J:67409 Lindsay EA, et al., Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in mice. Nature. 2001 Mar 1;410(6824):97-101
• All: 3 reference(s)