Del(16Cldn5-Hira)5Bld
Targeted Allele Detail

Summary

• Symbol: Del(16Cldn5-Hira)5Bld
• Name: deletion, Chr 16, Antonio Baldini 5
• MGI ID: MGI:3640128
• Synonyms: del(16)(Cld5-Hira), Del5Bld, Df(16)5, Df5
• Gene: Del(16Cldn5-Hira)5Bld Location: Chr16:18595597-18789059 bp Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110378
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutations: Intergenic deletion, Intragenic deletion
• Del(16Cldn5-Hira)5Bld involves 10 genes/genome features (Cldn5, Cdc45, Ufd1 ...) View all
• Mutation details: In an ES cell line in which a loxP site previously had been inserted into the Hira gene by homologous recombination, a second loxP site was inserted into the genome between the Gp1bb and Cldn5 genes using a retrovirus. Transient cre-expression in the ES cells resulted in deletion of a 150-kb region from Cldn5 to Hira. (J:110378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(16Cldn5-Hira)5Bld Mutation: 1 strain or line available

References

• Original: J:110378 Vitelli F, et al., Genetic dissection of the DiGeorge Syndrome Phenotype. Cold Spring Harb Symp Quant Biol. 2002;67:327-32
• All: 4 reference(s)