Ryr2^tm1.1Hta
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1.1Hta
• Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Hiroshi Takeshima
• MGI ID: MGI:3640298
• Synonyms: Crr^m2
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1.1Hta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48277
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Transient expression of cre recombinase in ES cells removed the first protein coding sequence of 48 base pairs and part of the first intron. (J:48277)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:48277 Takeshima H, et al., Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J. 1998 Jun 15;17(12):3309-16
• All: 5 reference(s)