Ms4a1^tm1Msn
Targeted Allele Detail

Summary

• Symbol: Ms4a1^tm1Msn
• Name: membrane-spanning 4-domains, subfamily A, member 1; targeted mutation 1, Michael S Neuberger
• MGI ID: MGI:3640301
• Synonyms: CD20^-
• Gene: Ms4a1 Location: Chr19:11227043-11243513 bp, - strand Genetic Position: Chr19, 8.19 cM, cytoband B
• Alliance: Ms4a1^tm1Msn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:48688
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encoding transmembranes 3 and 4 was replaced with a neomycin resistance cassette. Absence of transcript was confirmed by Northern blot analysis. (J:48688)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ms4a1 Mutation: 24 strains or lines available

Notes

These mice have a decrease in the IgM^hi 6B2- sub-population of peritoneal IgM+ cells but this is the result of a strain background effect and is also seen in mice of the 129/SvEv-Gpil^c strain (strain of origin for the CCB ES cell line).

References

• Original: J:48688 O'Keefe TL, et al., Mice carrying a CD20 gene disruption. Immunogenetics. 1998 Jul;48(2):125-32
• All: 2 reference(s)