Csn3^tm1Kuma
Targeted Allele Detail

Summary

• Symbol: Csn3^tm1Kuma
• Name: casein kappa; targeted mutation 1, Satish Kumar
• MGI ID: MGI:3640309
• Gene: Csn3 Location: Chr5:88073438-88080409 bp, + strand Genetic Position: Chr5, 43.56 cM
• Alliance: Csn3^tm1Kuma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110223
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.3 kb fragment including exon 1 and the 5' upstream region was replaced via homologous recombination with a loxP site, partial Hprt gene and neomycin gene. Northern blot analysis did not detect any mRNA; however, expression of other casein genes is similar to wild-type. (J:110223)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Csn3 Mutation: 18 strains or lines available

References

• Original: J:110223 Shekar PC, et al., kappa-casein-deficient mice fail to lactate. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8000-5
• All: 1 reference(s)