Ightm8(VHB1-8)Cgn
Targeted Allele Detail
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Symbol: |
Ightm8(VHB1-8)Cgn |
Name: |
immunoglobulin heavy chain complex; targeted mutation 8, University of Cologne |
MGI ID: |
MGI:3640326 |
Synonyms: |
Ightm8Cgn, pdelta deltaneo |
Gene: |
Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic
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Germline Transmission: |
Earliest citation of germline transmission:
J:48835
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted |
Mutation: |
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Insertion
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Mutation details: Through homologous recombination a modified version of the vector used to create Ightm2Cgn replaced the endogenous sequence. This vector replaces a 3' Igh-D element (DQ52) and Igh-J elements with a recombined antibody variable region derived from a 4-hydroxy-3-nitrophenyl acetyl binding antibody (B1-8), includes a termination codon in the leader exon of B1-8 and deletes the endogenous promoter.
(J:48835)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Igh Mutation: |
44 strains or lines available
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Original: |
J:48835 Fukita Y, et al., Somatic hypermutation in the heavy chain locus correlates with transcription. Immunity. 1998 Jul;9(1):105-14 |
All: |
3 reference(s) |
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