Gnmt^tm1Cwa
Targeted Allele Detail

Summary

• Symbol: Gnmt^tm1Cwa
• Name: glycine N-methyltransferase; targeted mutation 1, Conrad Wagner
• MGI ID: MGI:3640328
• Gene: Gnmt Location: Chr17:47036590-47040091 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband C
• Alliance: Gnmt^tm1Cwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110257
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first exon and promoter region were replaced with a neomycin resistance gene via homologous recombination. Western blot and enzyme activity assays did not detect any protein or activity in homozygous liver extracts. (J:110257)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnmt Mutation: 25 strains or lines available

References

• Original: J:110257 Luka Z, et al., A Glycine N-methyltransferase Knockout Mouse Model for Humans with Deficiency of this Enzyme. Transgenic Res. 2006 Jun;15(3):393-7
• All: 8 reference(s)