Dlk1^tm1Hsul
Targeted Allele Detail

Summary

• Symbol: Dlk1^tm1Hsul
• Name: delta like non-canonical Notch ligand 1; targeted mutation 1, Hei Sook Sul
• MGI ID: MGI:3640339
• Synonyms: Pref-1^-
• Gene: Dlk1 Location: Chr12:109418749-109429262 bp, + strand Genetic Position: Chr12, 60.17 cM, cytoband E-F1
• Alliance: Dlk1^tm1Hsul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted into exons 2 and 3. Western blot analysis of mutants failed to detect the multiple alternative splice products found in wild-type mice. (J:77909)

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dlk1 Mutation: 34 strains or lines available

References

• Original: J:77909 Moon YS, et al., Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol. 2002 Aug;22(15):5585-92
• All: 7 reference(s)