Hmgcl^tm1Gam
Targeted Allele Detail

Summary

• Symbol: Hmgcl^tm1Gam
• Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase; targeted mutation 1, Grant A Mitchell
• MGI ID: MGI:3640351
• Synonyms: HL^-
• Gene: Hmgcl Location: Chr4:135673776-135689926 bp, + strand Genetic Position: Chr4, 68.14 cM
• Alliance: Hmgcl^tm1Gam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52117
• Parent Cell Line: CGR8 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced by a neomycin resistance gene. (J:52117)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgcl Mutation: 15 strains or lines available

References

• Original: J:52117 Wang SP, et al., 3-Hydroxy-3-methylglutaryl-CoA lyase (HL): gene targeting causes prenatal lethality in HL-deficient mice. Hum Mol Genet. 1998 Dec;7(13):2057-62
• All: 1 reference(s)