Myc^tm1.1Dmlo
Targeted Allele Detail

Summary

• Symbol: Myc^tm1.1Dmlo
• Name: myelocytomatosis oncogene; targeted mutation 1.1, Dominique Morello
• MGI ID: MGI:3640383
• Synonyms: Delta3'SV
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1.1Dmlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70610
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Insertion
• Mutation details: Mice carrying the Myc^tm1Dmlo allele were crossed with mice expressing cre recombinase, resulting in the loss of the floxed neo while the human MYC carboxy terminal remained in place of the endogenous sequence and the 3'UTR was replaced by late SV40 3' UTR. (J:70610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:70610 Langa F, et al., Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited. Oncogene. 2001 Jul 19;20(32):4344-53
• All: 1 reference(s)