Myc^tm2Dmlo
Targeted Allele Detail

Summary

• Symbol: Myc^tm2Dmlo
• Name: myelocytomatosis oncogene; targeted mutation 2, Dominique Morello
• MGI ID: MGI:3640384
• Synonyms: Delta3'myc
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm2Dmlo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70610
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele contains a 159-nt long human MYC sequence encoding the carboxy terminal part of the protein in place of the corresponding mouse sequence. The allele contained a floxed neomycin resistance cassette with an RNA polymerase II promoter but without a polyA sequence immediately downstream of the MYC stop codon, which was subsequently removed by transient expression of cre recombinase. (J:70610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:70610 Langa F, et al., Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited. Oncogene. 2001 Jul 19;20(32):4344-53
• All: 1 reference(s)