Ednrb^tm1Myks
Targeted Allele Detail

Summary

• Symbol: Ednrb^tm1Myks
• Name: endothelin receptor type B; targeted mutation 1, Myung K Shin
• MGI ID: MGI:3640402
• Synonyms: Ednrb^lacZ
• Gene: Ednrb Location: Chr14:104052055-104081764 bp, - strand Genetic Position: Chr14, 53.05 cM
• Alliance: Ednrb^tm1Myks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84057
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to insert a LacZ into exon 1 immediately downstream of the ATG, replacing sequence encoding the extracellular domain and the first two transmembrane spanning domains. Cre mediated excision removed a floxed neo. (J:84057)

Expression

In Mice Carrying this Mutation:	127 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ednrb Mutation: 104 strains or lines available

References

• Original: J:84057 Lee HO, et al., The endothelin receptor-B is required for the migration of neural crest-derived melanocyte and enteric neuron precursors. Dev Biol. 2003 Jul 1;259(1):162-75
• All: 5 reference(s)