Cyp4a10^tm1Jhc
Targeted Allele Detail

Summary

• Symbol: Cyp4a10^tm1Jhc
• Name: cytochrome P450, family 4, subfamily a, polypeptide 10; targeted mutation 1, Jorge H Capdevila
• MGI ID: MGI:3640474
• Gene: Cyp4a10 Location: Chr4:115375484-115390846 bp, + strand Genetic Position: Chr4, 53.05 cM
• Alliance: Cyp4a10^tm1Jhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110364
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A gene segment including exon 3 and part of exon 4 was replaced with a neo cassette via homologous recombination. (J:110364)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp4a10 Mutation: 39 strains or lines available

References

• Original: J:110364 Nakagawa K, et al., Salt-sensitive hypertension is associated with dysfunctional Cyp4a10 gene and kidney epithelial sodium channel. J Clin Invest. 2006 Jun;116(6):1696-702
• All: 1 reference(s)