Tg(CAG-Btc)2Ewo
Transgene Detail

Summary

• Symbol: Tg(CAG-Btc)2Ewo
• Name: transgene insertion 2, Eckhard Wolf
• MGI ID: MGI:3640481
• Synonyms: Tg(ACTB-Btc)2Ewo, Tg(CAG-Btc)2Ewo
• Transgene: Tg(CAG-Btc)2Ewo Location: unknown
• Alliance: Tg(CAG-Btc)2Ewo page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-Btc)2Ewo expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Btc (MGI:99439)

• Mutation details: This transgene consists of the mouse Btc cDNA downstream of the cytomegalovirus enhancer, the chicken beta-actin promoter, and rabbit beta-globin splice acceptor and upstream to the rabbit beta-globin 3'-flanking region and polyadenylation signal and is referred to as L2. Btc is expressed ubiquitously, with highest expression in heart. lung, brain, and pancreas. (J:103364)

Expression

In Structures Affected by this Mutation:

20 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(CAG-Btc)2Ewo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:103364 Schneider MR, et al., Betacellulin overexpression in transgenic mice causes disproportionate growth, pulmonary hemorrhage syndrome, and complex eye pathology. Endocrinology. 2005 Dec;146(12):5237-46
• All: 6 reference(s)