Pregq3^NFS/N
QTL Variant Detail

Summary

• QTL variant: Pregq3^NFS/N
• Name: pregnancy QTL 3; NFS/N
• MGI ID: MGI:3640548
• QTL: Pregq3 Location: Chr13:20615512-72385189 bp Genetic Position: Chr13, cM position of peak correlated region/allele: 7.31 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: NFS/N

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109793

Linkage analysis was performed on 237 female animals from a (NFR/N x B10.Q-H2^q)F1 x B10.Q-H2^q backcross to map loci associated with reproductive performance traits. Parental strain NFR/N exhibits increased body size and better breeding properties compared to parental strain B10.Q-H2^q. Females were allowed to mate twice with B10.RIII males (allogenic matings) and twice with B10.Q-H2^q males (syngenic matings). Pregnancy rates and resulting litters were phenotyped.

On mouse Chromosome 1, linkage to litter size mapped to 9 cM near D1Mit67 (LOD=2.8). This locus is also significantly linked to neonatal growth (LOD=3.8) and is named Fecq3 (fecundity QTL 3). The QTL interval is flanked by markers D1Mit64 (5 cM) and D1Mit373 (17 cM). Homozygosity for B10.Q-H2^q-derived alleles at Fecq3 confers increased litter size. Linkage to maternal body weight at age 15 months was detected at 62 cM near D1Mit187 (LOD=4.5). This locus is named Bwq7 (body weight QTL 7). The QTL interval is flanked by markers D1Mit45 (58.5 cM) and D1Mit89 (63.1 cM). NFR/N-derived alleles at Bwq7 confer increased maternal body weight. Previously identified body weight QTLs Bw17 (69 cM) and Bwtq1 (54 cM) map near Bwq7. A locus showing suggestive linkage to maternally transmitted IgG at day 7 was detected at 63 cM near D1Mit89 (LOD=1.7). This interval is flanked by D1Mit187 (62 cM) and D1Mit14 (82 cM).

Suggestive linkage to neonatal growth in pups from allogenic matings mapped to 26.5 cM on mouse Chromosome 6 near D6Mit183 (LOD=3.0).

On mouse Chromosome 9, linkage to litter size (LOD=2.5) and neonatal growth (LOD=2.9) mapped to 31 cM near D9Mit21. This locus is named Fecq4 (fecundity QTL 4). The QTL interval is flanked by D9Mit130 (27 cM) and D9Mit48 (34 cM). NFR/N-derived alleles at Fecq4 confer increased litter size and neonatal growth. Linkage to neonatal growth, Neogq1, mapped to 42 cM near D9Mit8 (LOD=3.0). The QTL interval is flanked by D9Mit48 (34 cM) and D9Mit11 (48 cM). NFR/N-derived alleles at Neogq1 confer increased neonatal growth. This locus also shows suggestive linkage to neonatal growth specifically in allogenic matings (LOD=3.1) where B10.Q-H2^q-derived alleles confer increased neonatal growth in pups from allogenic matings. Foxb1 (41 cM) is a potential candidate gene mapping near Neogq1. Suggestive linkage to oocyte arrest mapped near this location in a study by Everett et al 2004 (J:93219).

On mouse Chromosome 11, linkage to pregnancy rate mapped to 2 locations named Pregq1 (pregnancy QTL 1) at 40 cM near D11Mit29(LOD=2.9) and Pregq2 (pregnancy QTL 2) at 64 cM near D11Mit360 (LOD=2.7). The Pregq1 interval is flanked by D11Mit23 (28 cM) and D11Mit36 (47 cM); the Pregq2 interval is flanked by D11Mit70 (54 cM) and D11Mit48 (77 cM). B10.Q-H2^q-derived alleles at Pregq1 and Pregq2 confer increased pregnancy rates. Pregq1 interacts epistatically with a locus at D10Mit198 on mouse Chromosome 10. (*Note, this marker has been renamed D9Mit1006 and is positioned on mouse Chromosome 9.) Animals heterozygous for NFR/N-derived alleles at Pregq1 and D9Mit1006 exhibit reduced pregnancy rates compared to animals homozygous for B10.Q-H2^q-derived alleles at Pregq1 and heterozygous at D9Mit1006. A potential candidate gene for Pregq2 is the Ace gene at 65 cM.

Significant linkage to pregnancy rate in allogenic matings mapped to 26 cM on mouse Chromosome 13 near D13Mit63 (LOD=3.1). This locus is named Pregq3 (pregnancy QTL 3). The QTL interval is flanked by D13Mit3 (10 cM) and D13Mit24 (43 cM). Homozygosity for B10.Q-H2^q-derivedalleles at Pregq3 confers increased pregnancy rates in allogenic matings. Suggestive linkage to maternally transmitted IgG mapped to 53 cM near D13Mit51 (LOD=1.7).

Highly significant linkage to pregnancy rate in allogenic matings mapped to 44.5 cM on mouse Chromosome 17 near D17Mit93 (LOD=4.1). This locus is named Pregq4 (pregnancy QTL 4). The QTL interval is flanked by D17Mit20 (34.3 cM) and D17Mit123 (56.7 cM). NFR/N-derived alleles at Pregq4 confer increased pregnancy rates in allogenic matings.

References

• Original: J:109793 Liljander M, et al., Identification of genetic regions of importance for reproductive performance in female mice. Genetics. 2006 Jun;173(2):901-9
• All: 1 reference(s)