Fecq4^NFS/N
QTL Variant Detail

Summary

• QTL variant: Fecq4^NFS/N
• Name: fecundity QTL 4; NFS/N
• MGI ID: MGI:3640564
• QTL: Fecq4 Location: Chr9:47543024-57805204 bp Genetic Position: Chr9, cM position of peak correlated region/allele: 25.91 cM
• QTL Note: genome coordinates based on the boundaries of the QTL region

Variant origin

• Strain of Specimen: NFS/N

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased litter size and neonatal growth compared to C57BL/10. (J:109793)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109793

Linkage analysis was performed on 237 female animals from a (NFR/N x B10.Q-H2^q)F1 x B10.Q-H2^q backcross to map loci associated with reproductive performance traits. Parental strain NFR/N exhibits increased body size and better breeding properties compared to parental strain B10.Q-H2^q. Females were allowed to mate twice with B10.RIII males (allogenic matings) and twice with B10.Q-H2^q males (syngenic matings). Pregnancy rates and resulting litters were phenotyped.

On mouse Chromosome 1, linkage to litter size mapped to 9 cM near D1Mit67 (LOD=2.8). This locus is also significantly linked to neonatal growth (LOD=3.8) and is named Fecq3 (fecundity QTL 3). The QTL interval is flanked by markers D1Mit64 (5 cM) and D1Mit373 (17 cM). Homozygosity for B10.Q-H2^q-derived alleles at Fecq3 confers increased litter size. Linkage to maternal body weight at age 15 months was detected at 62 cM near D1Mit187 (LOD=4.5). This locus is named Bwq7 (body weight QTL 7). The QTL interval is flanked by markers D1Mit45 (58.5 cM) and D1Mit89 (63.1 cM). NFR/N-derived alleles at Bwq7 confer increased maternal body weight. Previously identified body weight QTLs Bw17 (69 cM) and Bwtq1 (54 cM) map near Bwq7. A locus showing suggestive linkage to maternally transmitted IgG at day 7 was detected at 63 cM near D1Mit89 (LOD=1.7). This interval is flanked by D1Mit187 (62 cM) and D1Mit14 (82 cM).

Suggestive linkage to neonatal growth in pups from allogenic matings mapped to 26.5 cM on mouse Chromosome 6 near D6Mit183 (LOD=3.0).

On mouse Chromosome 9, linkage to litter size (LOD=2.5) and neonatal growth (LOD=2.9) mapped to 31 cM near D9Mit21. This locus is named Fecq4 (fecundity QTL 4). The QTL interval is flanked by D9Mit130 (27 cM) and D9Mit48 (34 cM). NFR/N-derived alleles at Fecq4 confer increased litter size and neonatal growth. Linkage to neonatal growth, Neogq1, mapped to 42 cM near D9Mit8 (LOD=3.0). The QTL interval is flanked by D9Mit48 (34 cM) and D9Mit11 (48 cM). NFR/N-derived alleles at Neogq1 confer increased neonatal growth. This locus also shows suggestive linkage to neonatal growth specifically in allogenic matings (LOD=3.1) where B10.Q-H2^q-derived alleles confer increased neonatal growth in pups from allogenic matings. Foxb1 (41 cM) is a potential candidate gene mapping near Neogq1. Suggestive linkage to oocyte arrest mapped near this location in a study by Everett et al 2004 (J:93219).

On mouse Chromosome 11, linkage to pregnancy rate mapped to 2 locations named Pregq1 (pregnancy QTL 1) at 40 cM near D11Mit29(LOD=2.9) and Pregq2 (pregnancy QTL 2) at 64 cM near D11Mit360 (LOD=2.7). The Pregq1 interval is flanked by D11Mit23 (28 cM) and D11Mit36 (47 cM); the Pregq2 interval is flanked by D11Mit70 (54 cM) and D11Mit48 (77 cM). B10.Q-H2^q-derived alleles at Pregq1 and Pregq2 confer increased pregnancy rates. Pregq1 interacts epistatically with a locus at D10Mit198 on mouse Chromosome 10. (*Note, this marker has been renamed D9Mit1006 and is positioned on mouse Chromosome 9.) Animals heterozygous for NFR/N-derived alleles at Pregq1 and D9Mit1006 exhibit reduced pregnancy rates compared to animals homozygous for B10.Q-H2^q-derived alleles at Pregq1 and heterozygous at D9Mit1006. A potential candidate gene for Pregq2 is the Ace gene at 65 cM.

Significant linkageto pregnancy rate in allogenic matings mapped to 26 cM on mouse Chromosome 13 near D13Mit63 (LOD=3.1). This locus is named Pregq3 (pregnancy QTL 3). The QTL interval is flanked by D13Mit3 (10 cM) and D13Mit24 (43 cM). Homozygosity for B10.Q-H2^q-derivedalleles at Pregq3 confers increased pregnancy rates in allogenic matings. Suggestive linkage to maternally transmitted IgG mapped to 53 cM near D13Mit51 (LOD=1.7).

Highly significant linkage to pregnancy rate in allogenic matings mapped to 44.5 cM on mouse Chromosome 17 near D17Mit93 (LOD=4.1). This locus is named Pregq4 (pregnancy QTL 4). The QTL interval is flanked by D17Mit20 (34.3 cM) and D17Mit123 (56.7 cM). NFR/N-derived alleles at Pregq4 confer increased pregnancy rates in allogenic matings.

J:153428

Fecq4 mapped to mouse Chromosome 9 in Liljander M Genetics 2006 Jun;173(2):901-9. Epub 2006 Mar 17(J:109793). The author genotyped B10.Q.NFR/N-Fecq4 congenic mice (Fecq4 locus of NFR/N origin on a B10.Q backgroubd ) in order to located genes that underlie the Fecq4 phenotype. The NFR/N congenic Fecq4 fragment in B10.Q.NFR/N-Fecq4 ranges from D9Mit27(50.4 Mbp) to D9Mit8(76.8 Mbp). Possible candidate genes for the Fecq4 phenotype within the NFR/N congenic region include Cyp19a1, Chrna3, Mpi, Cyp11a1,Bbs4, Dapk2 and Foxb1.

References

• Original: J:109793 Liljander M, et al., Identification of genetic regions of importance for reproductive performance in female mice. Genetics. 2006 Jun;173(2):901-9
• All: 1 reference(s)