Tg(Pomc1-cre)16Lowl
Transgene Detail

Summary

• Symbol: Tg(Pomc1-cre)16Lowl
• Name: transgene insertion 16, Bradford B Lowell
• MGI ID: MGI:3640616
• Synonyms: Pomc-Cre, Pomc-Cre(BAC1), Tg(Pomc1-cre)1Lowl
• Transgene: Tg(Pomc1-cre)16Lowl Location: unknown
• Alliance: Tg(Pomc1-cre)16Lowl page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Pomc1-cre)16Lowl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Pomc

• Mutation details: This transgene consists of a Pomc1 BAC such that cre is driven by Pomc1 regulatory elements. Cre is expressed in POMC neurons in the arcuate nucleus of the hypothalamus and scattered cre activity is also seen in the dentate gyrus of the hippocampus. (J:106354)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pomc (species not specified) Summary of all recombinase alleles driven by Pomc. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

31 assay results 1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Pomc1-cre)16Lowl

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:106354 Balthasar N, et al., Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24;42(6):983-91
• All: 160 reference(s)