Hoxc^tm1Nogu
Targeted Allele Detail

Summary

• Symbol: Hoxc^tm1Nogu
• Name: homeobox C cluster; targeted mutation 1, Shigeru Noguchi
• MGI ID: MGI:3640654
• Gene: Hoxc Location: unknown Genetic Position: Chr15, cytoband F1-F3

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61710
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Hoxc^tm1Nogu involves 12 genes/genome features (Hoxc13, Hoxc12, Hotair ...) View all
• Mutation details: Targeting constructs for the Hoxc-4 and Hoxc-13 genes were used to put loxP sites into a targeting vector. After electroporation of CCE ES cells with the targeting vector, homologous recombination produced doubly-targeted ES cells. Following introduction of a Cre expressing plasmid, deletion of 130 kb encompassing the Hoxc gene cluster resulted. (J:61710)

Expression

In Mice Carrying this Mutation:	175 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hoxc Mutation: 1 strain or line available

References

• Original: J:61710 Suemori H, et al., Hox C cluster genes are dispensable for overall body plan of mouse embryonic development. Dev Biol. 2000 Apr 15;220(2):333-42
• All: 7 reference(s)