Cnbp^m1Hrb
Transgenic Allele Detail

Summary

• Symbol: Cnbp^m1Hrb
• Name: cellular nucleic acid binding protein; mutation 1, Klaus Harbers
• MGI ID: MGI:3640662
• Synonyms: A8
• Gene: Cnbp Location: Chr6:87819597-87828088 bp, - strand Genetic Position: Chr6, 39.13 cM, cytoband D1-D2
• Alliance: Cnbp^m1Hrb page

Transgene origin

• Germline Transmission: Earliest citation of germline transmission: J:81582
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Transgene description

• Transgene Type: Transgenic
• Mutation: Viral insertion
• Mutation details: J1 ES cells were infected with mp10 virus carrying a neomycin resistance gene. After selection, resistant ES cell colonies were analyzed for the presence of single-copy proviral DNA. A mouse line established from one of these cell lines was shown to have an insertion in exon 1 of the Cnbp gene. Northern blots demonstrate that transcript levels are significantly reduced in heterozygous embryos and absent in homozygotes. (J:81582)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnbp Mutation: 30 strains or lines available

References

• Original: J:36254 Harbers K, et al., Provirus integration into a gene encoding a ubiquitin-conjugating enzyme results in a placental defect and embryonic lethality. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12412-7
• All: 3 reference(s)