Ctnnd1^tm1Lfr
Targeted Allele Detail

Summary

• Symbol: Ctnnd1^tm1Lfr
• Name: catenin delta 1; targeted mutation 1, Louis F Reichardt
• MGI ID: MGI:3640772
• Synonyms: p120ctn^flox
• Gene: Ctnnd1 Location: Chr2:84430415-84481109 bp, - strand Genetic Position: Chr2, 49.45 cM
• Alliance: Ctnnd1^tm1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110469
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 7 was flanked by loxP sites after removal of a FRT-flanked PGK-neo cassette. Cre-mediated deletion of exon 7 will result in a +2 frameshift in the transcriptional reading frame causing premature termination of transcription. (J:110469)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ctnnd1 Mutation: 122 strains or lines available

References

• Original: J:110469 Elia LP, et al., p120 catenin regulates dendritic spine and synapse development through Rho-family GTPases and cadherins. Neuron. 2006 Jul 6;51(1):43-56
• All: 5 reference(s)