Dnah11^lrm3
Chemically induced Allele Detail

Summary

• Symbol: Dnah11^lrm3
• Name: dynein, axonemal, heavy chain 11; left-right mutant 3
• MGI ID: MGI:3640793
• Gene: Dnah11 Location: Chr12:117841717-118162778 bp, - strand Genetic Position: Chr12, 63.25 cM
• Alliance: Dnah11^lrm3 page

Mutation origin

• Strain of Origin: BALB/cAnN

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in an ENU mutagenesis screen, was determined to be an allele of this gene by its failure to complement the original situs inversus viscerum mutation. The molecular defect has been identified as a GA-to-GT transversion in the splice donor sequence at the end of exon 30, which results in splicing out of exon 30. (J:145068)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnah11 Mutation: 217 strains or lines available

References

• Original: J:145068 Ermakov A, et al., Mouse mutagenesis identifies novel roles for left-right patterning genes in pulmonary, craniofacial, ocular, and limb development. Dev Dyn. 2009 Feb 22;238(3):581-594
• All: 2 reference(s)