Gucy1a1^tm1.1Dko
Targeted Allele Detail

Summary

• Symbol: Gucy1a1^tm1.1Dko
• Name: guanylate cyclase 1, soluble, alpha 1; targeted mutation 1.1, Doris Koesling
• MGI ID: MGI:3640804
• Synonyms: alpha1-KO
• Gene: Gucy1a1 Location: Chr3:81999734-82053096 bp, - strand Genetic Position: Chr3, 35.97 cM
• Alliance: Gucy1a1^tm1.1Dko page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110362
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was flanked with a loxP flanked neo cassette and a single loxP site via homologous recombination. Cre mediated recombination then removed exon 4. Western blot analysis confirmed the absence of protein expression in homozygous brain and lungs. (J:110362)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gucy1a1 Mutation: 42 strains or lines available

References

• Original: J:110362 Mergia E, et al., Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest. 2006 Jun;116(6):1731-7
• All: 10 reference(s)