Ocln^tm1Tshi
Targeted Allele Detail

Summary

• Symbol: Ocln^tm1Tshi
• Name: occludin; targeted mutation 1, Takashi Shinohara
• MGI ID: MGI:3641043
• Gene: Ocln Location: Chr13:100633015-100689226 bp, - strand Genetic Position: Chr13, 53.23 cM
• Alliance: Ocln^tm1Tshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110222
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 and DBA/2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3, encoding the amino-terminal half of the first transmembrane to the second extracellular loop, was replaced by a lacZ-loxP-neo-loxP cassette. This was the same construct used to generate Ocln^tm1Sts. (J:110222)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ocln Mutation: 33 strains or lines available

Notes

This mutation was generated using spermatogonial stem cells from mixed C57BL/6 and DBA/2 mice carrying Tg(ACTB-EGFP)Y01Osb.

References

• Original: J:110222 Kanatsu-Shinohara M, et al., Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8018-23
• All: 2 reference(s)