Tg(Inha-cre)3Zuk
Transgene Detail

Summary

• Symbol: Tg(Inha-cre)3Zuk
• Name: transgene insertion 3, Martin M Matzuk
• MGI ID: MGI:3641118
• Synonyms: alpha-iCre
• Transgene: Tg(Inha-cre)3Zuk Location: unknown
• Alliance: Tg(Inha-cre)3Zuk page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Inha-cre)3Zuk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Inha (MGI:96569)

• Mutation details: This transgene consists of a 6 kb fragment of the murine Inha promoter, an SV40 splice donor/splice acceptor intron sequence, an improved cre sequence, and an SV40 poly A tail. 3 lines were generated that differ in expression patterns. This line has high levels of activity in the testis and low activity in the ovary, adrenal gland and pituitary gland. (J:110150)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Inha (mouse) Summary of all recombinase alleles driven by Inha. Comparative matrix view of recombinase activities Alliance mouse Inha gene page

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Ptpn11^tm1Gsf/Ptpn11^tm1Gsf Tg(Inha-cre)3Zuk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Phenotypes:

Affected Systems	cn1
show or hide all annotated terms Sex:
endocrine/exocrine glands	√
seminiferous tubule degeneration	√
small testis	√
reproductive system	√
seminiferous tubule degeneration	√
small testis	√
arrest of spermatogenesis	√
male infertility	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:110150 Jorgez CJ, et al., Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal. Genesis. 2006 Apr;44(4):183-8
• All: 2 reference(s)