Asah2^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: Asah2^tm1Rlp
• Name: N-acylsphingosine amidohydrolase 2; targeted mutation 1, Richard L Proia
• MGI ID: MGI:3641171
• Synonyms: NcDase^-
• Gene: Asah2 Location: Chr19:31962046-32080540 bp, - strand Genetic Position: Chr19, 26.58 cM, cytoband C3
• Alliance: Asah2^tm1Rlp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110485
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• A targeting vector was designed to produce a deletion of part of exon 17 and the entire exon 18. (J:110585)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Asah2 Mutation: 40 strains or lines available

References

• Original: J:110485 Kono M, et al., Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. J Biol Chem. 2006 Mar 17;281(11):7324-31
• All: 9 reference(s)