Sh2d1b1^tm1Vei
Targeted Allele Detail

Summary

• Symbol: Sh2d1b1^tm1Vei
• Name: SH2 domain containing 1B1; targeted mutation 1, Andre Veillette
• MGI ID: MGI:3641174
• Synonyms: EAT-2-deficient, Sh2d1b^-/-
• Gene: Sh2d1b1 Location: Chr1:170104889-170114338 bp, + strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Sh2d1b1^tm1Vei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110195
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A targeting construct disrupted exon 2 of the gene creating a null allele. (J:110195)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d1b1 Mutation: 11 strains or lines available

References

• Original: J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
• All: 5 reference(s)