Jchain^tm3Tl
Targeted Allele Detail

Summary

• Symbol: Jchain^tm3Tl
• Name: immunoglobulin joining chain; targeted mutation 3, Tomas Leanderson
• MGI ID: MGI:3641196
• Synonyms: Igj^tm2Tl, J^-
• Gene: Jchain Location: Chr5:88667663-88675667 bp, - strand Genetic Position: Chr5, 43.7 cM
• Alliance: Jchain^tm3Tl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49168
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Deletion, Insertion
• Jchain^tm3Tl involves 1 genes/genome features (Jchain) View all
• Mutation details: A construct was designed to replace the first exon with the DTA gene followed by a neomycin resistance cassette flanked by loxP sites. Northern blot failed to detect transcript in mutants. (J:49168)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jchain Mutation: 24 strains or lines available

References

• Original: J:49168 Erlandsson L, et al., Mice with an inactivated joining chain locus have perturbed IgM secretion. Eur J Immunol. 1998 Aug;28(8):2355-65
• All: 8 reference(s)