Wnt7b^tm1Eem
Targeted Allele Detail

Summary

• Symbol: Wnt7b^tm1Eem
• Name: wingless-type MMTV integration site family, member 7B; targeted mutation 1, Edward E Morrisey
• MGI ID: MGI:3641208
• Synonyms: Wnt7b^lacZ
• Gene: Wnt7b Location: Chr15:85419638-85466022 bp, - strand Genetic Position: Chr15, 40.39 cM
• Alliance: Wnt7b^tm1Eem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79395
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1, including the ATG, with a lacZ-neo cassette. Unexpectedly, transcripts contining exons 3 and 4 were detected at low levels. LacZ expression recapitulates the endogenous expression pattern. (J:79395)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt7b Mutation: 17 strains or lines available

References

• Original: J:79395 Shu W, et al., Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development. 2002 Oct;129(20):4831-42
• All: 6 reference(s)