Hif1a^tm1Kats
Targeted Allele Detail

Summary

• Symbol: Hif1a^tm1Kats
• Name: hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Dorthe M Katschinski
• MGI ID: MGI:3641209
• Synonyms: HIF1aI.1^-
• Gene: Hif1a Location: Chr12:73948186-73994304 bp, + strand Genetic Position: Chr12, 31.99 cM
• Alliance: Hif1a^tm1Kats page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110340
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of the testis specific exon I.1 and an additional loxP site was introduced upstream of exon I.1. by homologous recombination. Cre mediated recombination removed the neo cassette and exon I.1. Expression of the ubiqutous isoform using exon I.2 was intact. (J:110340, J:117857)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hif1a Mutation: 50 strains or lines available

References

• Original: J:110340 Hagele S, et al., TSGA10 prevents nuclear localization of the hypoxia-inducible factor (HIF)-1alpha. FEBS Lett. 2006 Jun 26;580(15):3731-8
• All: 7 reference(s)