Plxna1^tm1Kik
Targeted Allele Detail

Summary

• Symbol: Plxna1^tm1Kik
• Name: plexin A1; targeted mutation 1, Hitoshi Kikutani
• MGI ID: MGI:3641211
• Synonyms: plexin-A1^-
• Gene: Plxna1 Location: Chr6:89293295-89339595 bp, - strand Genetic Position: Chr6, 39.91 cM, cytoband E2
• Alliance: Plxna1^tm1Kik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3 Kb fragment containing the second exon with the intitiation codon and the third exon with the coding sequence of the Sema-domain was replaced with a neo cassette. Deletion was confirmed by northern blotting an RT-PCR. (J:110786)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxna1 Mutation: 75 strains or lines available

References

• Original: J:110786 Takegahara N, et al., Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Nat Cell Biol. 2006 Jun;8(6):615-22
• All: 7 reference(s)