Ppp1r15a^tm1Kii
Targeted Allele Detail

Summary

• Symbol: Ppp1r15a^tm1Kii
• Name: protein phosphatase 1, regulatory subunit 15A; targeted mutation 1, Ken-ichi Isobe
• MGI ID: MGI:3641226
• Synonyms: Gadd34^-
• Gene: Ppp1r15a Location: Chr7:45172341-45175692 bp, - strand Genetic Position: Chr7, 29.34 cM, cytoband B2
• Alliance: Ppp1r15a^tm1Kii page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110590
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the 0.2 kb genomic fragment containing part of the second exon with a neo cassette. Western blot confirmed absence of protein in mutant MEFs. (J:110590)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r15a Mutation: 23 strains or lines available

References

• Original: J:110590 Kojima E, et al., The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. FASEB J. 2003 Aug;17(11):1573-5
• All: 10 reference(s)