Tlr6^int
Chemically induced Allele Detail

Summary

• Symbol: Tlr6^int
• Name: toll-like receptor 6; insouciant
• MGI ID: MGI:3641228
• Synonyms: Int, Tlr6^inst, Tlr6^m1Btlr
• Gene: Tlr6 Location: Chr5:65109374-65117440 bp, - strand Genetic Position: Chr5, 33.54 cM
• Alliance: Tlr6^int page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in a screen of G3 progeny of ENU treated mice for responses to various toll-like receptor ligands, is an A-to-G transition resulting in replacement of valine by alanine at amino acid 327 (V327A), between the second and third leucine-rich domains of the extracellular part of the protein. (J:86521, J:110094)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tlr6 Mutation: 50 strains or lines available

References

• Original: J:110094 Jiang Z, et al., Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6
• All: 6 reference(s)