Myd88^lkd
Chemically induced Allele Detail

Summary

• Symbol: Myd88^lkd
• Name: myeloid differentiation primary response gene 88; lackadaisical
• MGI ID: MGI:3641234
• Synonyms: Lkd, Myd88^m1Btlr
• Gene: Myd88 Location: Chr9:119165000-119169084 bp, - strand Genetic Position: Chr9, 71.33 cM
• Alliance: Myd88^lkd page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, identified in a screen of G3 progeny of ENU treated mice for responses to various toll-like receptor ligands, is an A-to-G transition resulting in replacement of tyrosine with cysteine at amino acid 116 (Y116C), between the death domain (aa 19-109) and the toll-interleukin 1 receptor (TIR) domain (aa 160-296) of the protein. (J:86521, J:110094)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myd88 Mutation: 52 strains or lines available

Notes

Genbank ID for this allele: DQ790886

References

• Original: J:110094 Jiang Z, et al., Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):10961-6
• All: 3 reference(s)