Robo1^tm1.1Ljr
Targeted Allele Detail

Summary

• Symbol: Robo1^tm1.1Ljr
• Name: roundabout guidance receptor 1; targeted mutation 1.1, Linda J Richards
• MGI ID: MGI:3641236
• Synonyms: Robo1^-
• Gene: Robo1 Location: Chr16:72105194-72842983 bp, + strand Genetic Position: Chr16, 41.08 cM
• Alliance: Robo1^tm1.1Ljr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109478
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 5 was removed via cre-mediated recombination. RT-PCR confirmed absence of wild-type transcript in mutants. Western blot failed to detect protein. (J:109478)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Robo1 Mutation: 87 strains or lines available

References

• Original: J:109478 Andrews W, et al., Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain. Development. 2006 Jun;133(11):2243-52
• All: 5 reference(s)