Kmt2a^tm1Djab
Targeted Allele Detail

Summary

• Symbol: Kmt2a^tm1Djab
• Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Malek Djabali
• MGI ID: MGI:3641250
• Synonyms: deltaSET, MlldeltaSET-
• Gene: Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Kmt2a^tm1Djab page

Skeletal abnormalities in Kmt2a^tm1Djab/Kmt2a^tm1Djab mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109102
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The SET domain was replaced with a floxed neomycin resistance gene. A stop codon was introduced in frame to allow termination of protein synthesis in the absence of the SET domain. RT-PCR demonstrated that mutant transcript was expressed at the same levels as wild-type transcripts. (J:109102)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2a Mutation: 135 strains or lines available

References

• Original: J:109102 Terranova R, et al., Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6629-34
• All: 3 reference(s)