Tbx1^{tm1(Fgf8)Vite}
Targeted Allele Detail

Summary

• Symbol: Tbx1^{tm1(Fgf8)Vite}
• Name: T-box 1; targeted mutation 1, Francesca Vitelli
• MGI ID: MGI:3641283
• Synonyms: Tbx1^Fgf8
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^{tm1(Fgf8)Vite} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110620
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 0.8 kb Fgf8 cDNA encoding isoform 8b into exon 5 of the Tbx1 gene which encodes a portion of the essential T-box domain. (J:110620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:110620 Vitelli F, et al., Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol. 2006 Jul 15;295(2):559-70
• All: 3 reference(s)