Slc2a8^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Slc2a8^tm1.1Thor
• Name: solute carrier family 2, (facilitated glucose transporter), member 8; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:3641337
• Synonyms: glut8^-
• Gene: Slc2a8 Location: Chr2:32863002-32872095 bp, - strand Genetic Position: Chr2, 22.09 cM
• Alliance: Slc2a8^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109701
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 10 was removed via cre-mediated recombination. A neomycin resistance cassette flanked by frt sites remained in the locus. Northern blot analysis confirmed absence of mRNA in the brain, testis and liver of homozygous mutant mice. (J:109701)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc2a8 Mutation: 19 strains or lines available

References

• Original: J:109701 Membrez M, et al., GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function. Mol Cell Biol. 2006 Jun;26(11):4268-76
• All: 1 reference(s)