Chd4^tm1.2Kge
Targeted Allele Detail

Summary

• Symbol: Chd4^tm1.2Kge
• Name: chromodomain helicase DNA binding protein 4; targeted mutation 1.2, Katia Georgopoulos
• MGI ID: MGI:3641409
• Synonyms: Mi-2beta^delta
• Gene: Chd4 Location: Chr6:125073144-125107554 bp, + strand Genetic Position: Chr6, 59.28 cM
• Alliance: Chd4^tm1.2Kge page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109547
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 12-21 were removed via cre-mediated recombination, resulting in the production of a transcript lacking exons 12-21, but containing downstream sequences. A truncated protein was not detected. (J:109547)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd4 Mutation: 58 strains or lines available

References

• Original: J:109547 Williams CJ, et al., The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development. Immunity. 2004 Jun;20(6):719-33
• All: 2 reference(s)