Xrcc4^tm2Fwa
Targeted Allele Detail

Summary

• Symbol: Xrcc4^tm2Fwa
• Name: X-ray repair complementing defective repair in Chinese hamster cells 4; targeted mutation 2, Frederick W Alt
• MGI ID: MGI:3641440
• Synonyms: X^c, Xrcc4^c
• Gene: Xrcc4 Location: Chr13:89997033-90237727 bp, - strand Genetic Position: Chr13, 45.5 cM
• Alliance: Xrcc4^tm2Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109585
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites flanked exon 3 by homologous recombination. (J:109585)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Xrcc4^tm2Fwa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xrcc4 Mutation: 26 strains or lines available

References

• Original: J:109585 Yan CT, et al., XRCC4 suppresses medulloblastomas with recurrent translocations in p53-deficient mice. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7378-83
• All: 15 reference(s)