Bfsp1^tm1Pgf
Targeted Allele Detail

Summary

• Symbol: Bfsp1^tm1Pgf
• Name: beaded filament structural protein 1, in lens-CP94; targeted mutation 1, Paul G FitzGerald
• MGI ID: MGI:3641549
• Synonyms: filensin^ko
• Gene: Bfsp1 Location: Chr2:143668448-143705093 bp, - strand Genetic Position: Chr2, 70.89 cM, cytoband G
• Alliance: Bfsp1^tm1Pgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109599
• Parent Cell Line: GK129 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A pgk-neo cassette replaced exon 1, promoter elements and the transcriptional start site. Northern blot confirmed absence of transcript in mutant lenses. (J:109599)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bfsp1 Mutation: 33 strains or lines available

References

• Original: J:109599 Alizadeh A, et al., Targeted deletion of the lens fiber cell-specific intermediate filament protein filensin. Invest Ophthalmol Vis Sci. 2003 Dec;44(12):5252-8
• All: 3 reference(s)